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The Lancet

http://www.thelancet.com/journals/lancet/article/PIIS0140-6736(10)60518-1/fulltext

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12 April 2010

 

MATERNAL MORTALITY for 181 COUNTRIES, 1980—2008: A Systematic Analysis of Progress Towards Millennium Development Goal 5

 

Original Text

Margaret C Hogan MSc a b, Kyle J Foreman AB a, Mohsen Naghavi MD a, Stephanie Y Ahn BA a, Mengru Wang BA a, Susanna M Makela BS a, Prof Alan D Lopez PhD c, Prof Rafael Lozano MD a, Prof Christopher JL Murray MD a

Summary

Background

Maternal mortality remains a major challenge to health systems worldwide. Reliable information about the rates and trends in maternal mortality is essential for resource mobilisation, and for planning and assessment of progress towards Millennium Development Goal 5 (MDG 5), the target for which is a 75% reduction in the maternal mortality ratio (MMR) from 1990 to 2015. We assessed levels and trends in maternal mortality for 181 countries.

Methods

We constructed a database of 2651 observations of maternal mortality for 181 countries for 1980—2008, from vital registration data, censuses, surveys, and verbal autopsy studies. We used robust analytical methods to generate estimates of maternal deaths and the MMR for each year between 1980 and 2008. We explored the sensitivity of our data to model specification and show the out-of-sample predictive validity of our methods.

Findings

We estimated that there were 342 900 (uncertainty interval 302 100—394 300) maternal deaths worldwide in 2008, down from 526 300 (446 400—629 600) in 1980. The global MMR decreased from 422 (358—505) in 1980 to 320 (272—388) in 1990, and was 251 (221—289) per 100 000 livebirths in 2008. The yearly rate of decline of the global MMR since 1990 was 1·3% (1·0—1·5). During 1990—2008, rates of yearly decline in the MMR varied between countries, from 8·8% (8·7—14·1) in the Maldives to an increase of 5·5% (5·2—5·6) in Zimbabwe. More than 50% of all maternal deaths were in only six countries in 2008 (India, Nigeria, Pakistan, Afghanistan, Ethiopia, and the Democratic Republic of the Congo). In the absence of HIV, there would have been 281 500 (243 900—327 900) maternal deaths worldwide in 2008.

Interpretation

Substantial, albeit varied, progress has been made towards MDG 5. Although only 23 countries are on track to achieve a 75% decrease in MMR by 2015, countries such as Egypt, China, Ecuador, and Bolivia have been achieving accelerated progress.

Funding

Bill & Melinda Gates Foundation.

Introduction

Maternal mortality—the death of women during pregnancy, childbirth, or in the 42 days after delivery—remains a major challenge to health systems worldwide. Global initiatives to intensify policy intervention for maternal mortality began with the Safe Motherhood Initiative in 1987,1 a response to growing recognition that primary health-care programmes in many developing countries were not adequately focused on maternal health.2 The 1994 International Conference on Population and Development strengthened international commitment to reproductive health.3, 4 The focus on maternal mortality was sharpened when reduction in maternal mortality became one of eight goals for development in the Millennium Declaration (Millennium Development Goal [MDG] 5).5 The target for MDG 5 is to reduce the maternal mortality ratio (MMR) by three-quarters from 1990 to 2015.6 There is a widespread perception that progress in maternal mortality has been slow, and in many places non-existent.7—9 Acceleration of progress in maternal mortality has received renewed policy attention in the USA through the Obama administration's proposed Global Health Initiative,10 and high-profile civil society groups such as the White Ribbon Alliance continue to bring further attention.

The need for accurate monitoring of maternal mortality has long been recognised, both to advocate for resources and policy attention and to track progress.11—13 Maternal mortality, however, is considered very difficult to measure.14—17 Several efforts have been made over nearly three decades to improve the quality of information about maternal mortality, including the incorporation of sibling history modules in the Demographic and Health Surveys (DHS) and similar surveys;18, 19 the inclusion of questions about whether recent deaths were related to pregnancy in censuses;20, 21 and the use of record linkage or confidential enquiry to identify under-registration of maternal deaths in vital registration systems.22, 23

Beginning in 1996, WHO sponsored the development of country estimates of maternal mortality for 1990, 1995, 2000, and 2005.24—27 The most recent assessment of maternal mortality, which was jointly sponsored by WHO, UNICEF, UNFPA, and the World Bank, reported 576 300 maternal deaths globally in 1990, and 535 900 maternal deaths in 2005—a 0·48% yearly rate of decline.7 The corresponding decrease in the global MMR (the number of maternal deaths per 100 000 livebirths) was 0·37% per year. As a separate analysis, Hill and colleagues7 estimated a rate of decline of 2·5% per year for a subset of 125 countries with more than one observation. For the two results to be consistent, a substantial proportion of the countries without multiple observations must have had increases in the MMR.

In view of the continued prominence of maternal mortality as a health and development goal, global rates and trends in maternal mortality need to be reassessed. Recent developments provide an opportunity for substantially improved estimates of maternal mortality. First, the Global Burden of Disease (GBD) study28 has undertaken a detailed analysis of vital registration data to identify misclassified deaths from causes such as maternal mortality. Second, methodological advances allow for the correction of known biases in survey sibling history data, including whether sibling deaths are from maternal causes.29 Third, population-based verbal autopsy studies have been done that measure maternal mortality both nationally and subnationally. Fourth, a systematic assessment of data sources for adult female mortality has provided estimates of mortality for women of reproductive age (15—49 years) from 1970 to 2010.30 Finally, methodological developments in other areas have provided improved methods for estimation. In this study, we used all available data to assess levels and trends in maternal mortality from 1980 to 2008 for 181 countries.

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Discussion

Our analysis of all available data for maternal mortality from 1980 to 2008 for 181 countries has shown a substantial decline in maternal deaths. Progress overall would have been greater if the HIV epidemic had not contributed to substantial increases in maternal mortality in eastern and southern Africa. Global progress to reduce the MMR has been similar to progress to reduce maternal deaths, since the size of the global birth cohort has changed little during this period. Across countries, average yearly rates of decline from 1980 to 2008 in the MMR differed widely. This new evidence suggests there is a much greater reason for optimism than has been generally perceived, and that substantial decreases in the MMR are possible over a fairly short time.

Global progress to reduce the MMR should perhaps not be seen as surprising. Four powerful drivers of maternal mortality are improving in most countries. First, the global TFR has dropped from 3·70 in 1980, to 3·26 in 1990 and 2·56 in 2008. Despite rising numbers of women of reproductive age, the decrease in TFR has kept the size of the global birth cohort stable. In addition to the direct effect of fertility on exposure to risk of maternal death,57 the MMR and TFR are strongly correlated.5, 58 Societies in which the TFR decreases are also places with declines in the MMR—whether this relation is causal or mediated through social change that drives both is not clear. Second, income per head, which can affect maternal mortality through several channels from nutritional status of mothers to physical and financial access to health care,59 has been rising particularly in Asia and Latin America. Third, maternal educational attainment, another strong correlate of maternal mortality, has been rising—eg, average years of schooling of women aged 25—44 years in sub-Saharan Africa increased from 1·5 in 1980 to 4·4 in 2008. Finally, although we did not include the proportion of women giving birth with a skilled attendant as a covariate in our model because of collinearity, the steady, albeit slow, rise in coverage of skilled birth attendance could have contributed to maternal mortality declines.60 Further, some large countries such as India have witnessed quite rapid increases in skilled birth attendance in recent years.61 The combination of these factors suggests that a finding that the global MMR was not declining would be more surprising.

Our analysis, in line with previous studies,5, 62, 63 draws attention to the important adverse effect of the HIV epidemic on the MMR, especially in east and southern Africa. In the absence of HIV, progress in sub-Saharan Africa in reducing the MMR would have been much more extensive than we recorded. The counterfactual analysis of the MMR without HIV-related deaths has important implications for intervention policy. The set of interventions for dealing with HIV infection in pregnant or post-partum women would include access to antiretroviral drugs, which is not part of the set of maternal health interventions targeting women who are HIV negative. Tracking of HIV-related maternal mortality is important but challenging in settings without vital registration. In countries with complete vital registration systems, including South Africa,30 the use of a checkbox to identify women who were pregnant at the time of death or within 42 days before death could be a useful adjunct.22, 64

Some countries have had much success in reducing the MMR. In 1990—2008, countries with substantial declines in MMR included Egypt, Romania, Bangladesh, India, and China. In some cases, policy case studies have been written about these countries.65—70 In others, no policy analyses have yet been published. Although our analysis does not provide explanations for these accelerated decreases, we hope that the results will stimulate detailed policy reviews. By contrast, some countries that are judged to be successful in terms of maternal mortality, such as Indonesia, have not had particularly rapid declines in this ratio.71 In these cases, whether there are other data sources missing that would change the estimated trend or whether there is a disconnect between increases in skilled birth attendance or other maternal health interventions and actual changes in the MMR needs to be explored.

Comparison of pairs of countries shows the complexity of understanding trends in the MMR. From 1990 to 2008, the MMR decreased 1·9% every year in Mexico and 3·9% in Brazil. Both are large complex federal states that have had many improvements in adult mortality mediated through social, economic, and health-system change. Both have placed substantial policy emphasis to reduce maternal mortality,72, 73 but Brazil has outperformed Mexico in terms of declines. In Asia, India and Indonesia have achieved substantially different rates of decline. In 1980, the MMR was 677 in India, which was substantially higher than the ratio of 423 in Indonesia. Over the MDG period, India has seen a yearly rate of decline of 4·0%, whereas Indonesia has lagged with a yearly decrease of only 0·6%. This differential performance means that the two countries now have similar MMRs.

Egypt and Turkey provide another interesting comparison. Egypt has seen an impressive improvement from 1990 to 2008, with a yearly decrease of 8·4%, whereas Turkey has seen a slower rate of decline of only 4·2%. In 1990, the ratio of MMRs in Egypt compared with Turkey was 1·6, but after nearly 20 years of steady progress in Egypt, Turkey now has a higher MMR than Egypt, with a ratio of 1·3.

One of the most surprising results is the apparent rise in the MMR in the USA, Canada, and Norway. This finding is likely to be partly explained by the introduction of late maternal deaths in the ICD 10, and the inclusion of a separate pregnancy status question on the US death certificate.74 This addition to the US death certificate was intended to improve ascertainment of pregnancy-related deaths, which our results suggest that it has done. However, it raises important questions about how these maternal deaths were being coded before the introduction of the pregnancy status question on the death certificate.

Our results for 2005 differ substantially from the assessment undertaken by Hill and colleagues.7 This discrepancy could have several explanations. First, we used a dataset with nearly three times as many observations as Hill and co-workers had. Second, Hill and colleagues modelled the proportion of deaths in women of reproductive age, which is likely to be confounded by the rise of HIV infections. Other investigators have questioned the choice of the proportion as the dependent variable.75 We modelled the maternal mortality rate. Third, our method captures systematic spatial and temporal variation, shown by improved performance in predictive validity tests. Fourth, this study used improved adult mortality estimates based on a systematic assessment of all available data. Finally, Hill and colleagues developed subjective uncertainty intervals for each country and then made the unusual assumption that uncertainty across countries was perfectly correlated in the generation of global and regional uncertainty intervals; we have taken an approach that uses a statistical framework.

Our study has several important limitations. In countries with complete vital registration systems, we might be overestimating maternal deaths. We have used data for cause of death in which the misclassification of maternal deaths to causes such as septicaemia has been carefully corrected. Vital registration data, however, also include late maternal deaths that occur after 42 days. The UN MDG and ICD manuals recommend that late maternal deaths should not be counted in the MMR but, in most countries, we are unable to identify these deaths from the vital registration data. The proportion of late maternal deaths is probably higher in countries with low MMR than in those with high ratios.35, 74

In countries with incomplete vital registration systems, we could be underestimating the proportion of deaths attributable to maternal causes. Although vital registration data used in our model have been corrected for misclassification, the proportion might be biased downwards if an incomplete system excludes populations at increased risk of maternal death.

For countries in which the primary source of data is surveys or censuses, our numerator includes incidental deaths in pregnant women from causes such as motor vehicle accidents, burning, or drowning. These deaths should not be counted as maternal deaths since they would bias our estimates upwards, but no clear analytical strategy is available to identify the proportion of pregnancy-related deaths that are incidental. Other analysts have suggested that any overcounting resulting from the incidental deaths captured by these methods will be offset by undercounting because of respondents not knowing about the pregnancy or not wishing to identify a pregnancy;7, 76 however, evidence for this claim is scarce.

Another important limitation is that 21 countries had no data for the entire period from 1980 to 2008. However, the predictive validity results suggest that our model does reasonably well out of sample. Countries with no data could be particularly affected by uncertainty in the covariates, which we have not incorporated into our estimates of uncertainty.

Lastly, for countries that do have data from several sources, such as India, there can be substantial non-sampling error across data sources. Inconsistencies between different datasets have meant that investigators need to make informed, but arbitrary, choices about which set to include. Future data collection or studies might provide new insights that could change the identification of which sources are outliers.

Compared with previous assessments of maternal mortality, we have narrowed the uncertainty around global and national estimates of the MMR. This improved accuracy is a result of an extensive database and the use of analytical methods with increased explanatory power and improved out-of-sample predictive validity. Nevertheless, our uncertainty intervals are biased towards being too large.

On the basis of our systematic assessment, we are optimistic about the ability to monitor maternal mortality over time. More data are available for maternal mortality than for other main causes of child or adult death. For example, WHO estimates more than 200 000 deaths from tuberculosis in reproductive-aged women,77 yet in countries of low and lower-middle income the number of data points directly measuring tuberculosis as a cause of death is much lower than that for maternal mortality. A comparison of the information base for maternal mortality compared with HIV and many causes of child mortality is similarly favourable.78, 79 Of leading causes of death in children and adults in developing countries, there are more empirical observations for maternal mortality than for any other cause. Continued efforts at strengthening vital registration and the expansion of data collection for pregnancy-related mortality through household surveys and censuses should further strengthen the global database. However, continuing surveillance of all-cause adult female mortality as an input to tracking maternal mortality is crucial.

This analysis has shown that although countries can achieve substantial progress in reduction of maternal deaths, far too many have not done so. In 5 years, the global health community and country governments will be held accountable for their achievement of the MDGs. Progress needs to be accelerated in countries where further substantial reductions in maternal mortality should be achievable with heath-system reform. The delivery of interventions to women when and where they need them ought to be a purposeful policy of all countries.

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The New York Times

 

April 13, 2010

 

MATERNAL DEATHS DECLINE SHARPLY ACROSS THE GLOBE

By DENISE GRADY

For the first time in decades, researchers are reporting a significant drop worldwide in the number of women dying each year from pregnancy and childbirth, to about 342,900 in 2008 from 526,300 in 1980.

The findings, published in the medical journal The Lancet, challenge the prevailing view of maternal mortality as an intractable problem that has defied every effort to solve it.

“The overall message, for the first time in a generation, is one of persistent and welcome progress,” the journal’s editor, Dr. Richard Horton, wrote in a comment accompanying the article, published online on Monday.

The study cited a number of reasons for the improvement: lower pregnancy rates in some countries; higher income, which improves nutrition and access to health care; more education for women; and the increasing availability of “skilled attendants” — people with some medical training — to help women give birth. Improvements in large countries like India and China helped to drive down the overall death rates.

But some advocates for women’s health tried to pressure The Lancet into delaying publication of the new findings, fearing that good news would detract from the urgency of their cause, Dr. Horton said in a telephone interview.

“I think this is one of those instances when science and advocacy can conflict,” he said.

Dr. Horton said the advocates, whom he declined to name, wanted the new information held and released only after certain meetings about maternal and child health had already taken place.

He said the meetings included one at the United Nations this week, and another to be held in Washington in June, where advocates hope to win support for more foreign aid for maternal health from Secretary of State Hillary Rodham Clinton. Other meetings of concern to the advocates are the Pacific Health Summit in June, and the United Nations General Assembly meeting in December.

“People who have spent many years committed to the issue of maternal health were understandably worried that these figures could divert attention from an issue that they care passionately about,” Dr. Horton said. “But my feeling is that they are misguided in their view that this would be damaging. My view is that actually these numbers help their cause, not hinder it.”

He said the new study was based on more and better data, and more sophisticated statistical methods than were used in a previous analysis by a different research team that estimated more deaths, 535,900 in 2005. The authors of the earlier analysis, published in The Lancet, in 2007, included researchers from Unicef, Harvard, the World Bank, the World Health Organization and the Johns Hopkins School of Public Health. The World Health Organization still reports about half a million maternal deaths a year, but is expected to issue new statistics of its own this year.

The new report comes from the University of Washington and the University of Queensland in Brisbane, Australia, and was paid for by the Bill and Melinda Gates Foundation.

A spokesman for Unicef said it had no comment on the new findings, and there was no response to messages that were left late Tuesday for W.H.O. officials.

Dr. Christopher J. L. Murray, the director of the institute for health metrics and evaluation at the University of Washington, in Seattle, and an author of the study, said, “There has been a perception of no progress.”

But, he said, “some of the policies and programs pursued may be having an effect, as opposed to all that effort with little to show for it.”

“It really is an important positive finding for global health,” he said.

Dr. Murray said no one had approached him directly about delaying the release of his findings; he heard about those efforts from The Lancet, and described them as “disappointing.” He said, “We believe in the process of peer-reviewed science, and it’s the proper way to pursue these sorts of studies.”

The researchers analyzed maternal mortality in 181 countries from 1980 to 2008, using whatever information they could glean from each country: death records, censuses, surveys and published studies. They ultimately gathered about three times as much data as the previous researchers had found.

Among poor countries with longstanding high death rates, progress varied considerably. For instance, from 1990 to 2008, the maternal death rate dropped 8.8 percent a year in the Maldives, but rose 5.5 percent in Zimbabwe. Sub-Saharan Africa has the highest maternal death rates. Brazil improved more than Mexico, Egypt more than Turkey. Six countries accounted for more than half of all the maternal deaths in 2008: India, Nigeria, Pakistan, Afghanistan, Ethiopia and the Democratic Republic of Congo.

But India has made steady progress, and because its population is so large, its improvements have helped considerably to decrease the worldwide rate of maternal deaths. China has also made considerable progress. In India, there were 408 to 1,080 maternal deaths per 100,000 live births in 1980, and by 2008, there were 154 to 395, the new study found. In China, there were 144 to 187 deaths per 100,000 live births in 1980, and 35 to 46 in 2008.

Dr. Murray said the findings came as a surprise. What also surprised him and his colleagues, he said, was the number of pregnant women who died from AIDS: about 60,000.

“Really to a large extent that’s why maternal mortality is rising in eastern and southern Africa,” Dr. Murray said.

“It means, to us, that if you want to tackle maternal mortality in those regions, you need to pay attention to the management of H.I.V. in pregnant women. It’s not about emergency obstetrical care, but about access to antiretrovirals.”

Dr. Horton contended that the new data should encourage politicians to spend more on pregnancy-related health matters. The data dispelled the belief that the statistics had been stuck in one dismal place for decades, he said. So money allocated to women’s health is actually accomplishing something, he said, and governments are not throwing good money after bad.

An advocate for women’s health, Dr. Flavia Bustreo, director of the Partnership for Maternal, Newborn and Child Health, said the improvements described in the new report represented “hope at last.” She said her organization, affiliated with the World Health Organization, was not one of those that tried to delay release of the findings.

She said the report was well done and called The Lancet a “scrupulously” edited journal. She said the findings made sense and were consistent with other reports from large countries like India, which can drive global figures.

“For 20 years, the safe motherhood movement has been conveying an impression of no progress,” Dr. Bustreo said. “To hear confirmation of improvements is good news. To us, the good news will maintain the interest of investors. If you don’t show results, that’s the worst position you can be in. The evidence and scientific truths have to be put in the open and discussed.”

Her group issued its own report on Tuesday, noting improvements that were saving the lives of women during pregnancy and birth in various countries. For instance, India pays women to get prenatal care and skilled care for delivery. Nepal provides home visits for family planning. Malawi is training nonphysicians to perform emergency Caesarean sections. Brazil has set up a health system that provides free primary care and skilled attendance at birth for all. ________________________________________________________________

BBC - Related Article - http://news.bbc.co.uk/2/hi/health/8616250.stm

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